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Publication name:	Jelinski_Rpn4
Title:	Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: Rpn4 links base excision repair with proteasomes.
Authors:	Jelinsky SA, Estep P, Church GM, Samson LD
Ref:	"Mol Cell Biol 2000 Nov;20(21):8157-67"
Links:	Publication website Medline On line article
Experiments: 30	Organism: Budding yeast (Saccharomyces cerevisiae)
Slide type:	microarrays oligos
Comment:
Condition Green Red Ratio min Ratio max log2 avg Std dev ORFs measured -3 fold -2 fold -1.5 fold +1.5 fold +2 fold +3 fold log2(ratio) distrib average MMS No drug 0.1% MMS, 1h exposure 0.02 50.30 0.34 0.98 6079 174 448 764 2358 1353 497 MMS No drug 0.1% MMS, 1h exposure 0.01 54.70 0.34 1.06 6079 228 523 892 2387 1500 580 RPN4/log wild type rpn4 deletant 0.01 50.20 0.01 1.07 6080 374 857 1464 1499 913 388 RPN4mms/RPN4 rpn4 deletant mock treatment rpn4 deletant 0.1%MMS 1h exposure 0.02 90.40 0.10 1.21 6080 483 829 1241 1999 1270 543 G1 unsynchronised cells cells in G1 0.03 70.60 -0.03 0.77 6079 168 460 1023 973 416 133 S unsynchronised cells cells in S phase 0.10 17.20 0.02 0.68 6080 75 310 851 955 405 129 G2 unsynchronised cells cells in G2 0.11 27.50 0.02 0.60 6080 42 223 686 816 286 73 G1_exp2 unsynchronised cells cells in G1 0.04 90.90 0.26 1.07 6079 282 584 1014 2203 1402 599 S_exp2 unsynchronised cells cells in S phase 0.04 37.90 0.29 0.97 6080 221 489 804 2182 1272 426 G2_exp2 unsynchronised cells cells in G2 0.04 33.20 0.24 0.98 6078 224 547 924 2078 1203 425 G1MMS cells in G1 cells in G1 0.1%MMS 1h exposure 0.01 83.60 0.23 1.15 6077 359 652 1054 2242 1472 588 SMMS cells in S phase cells in S phase 0.1%MMS 1h exposure 0.02 76.40 0.33 1.15 6078 346 596 926 2376 1511 611 G2MMS cells in G2 cells in G2 0.1%MMS 1h exposure 0.03 74.80 0.26 1.09 6079 299 592 952 2236 1362 534 STAT cells in log phase cells in stationnary phase 0.01 93.10 0.24 1.22 6074 347 691 1124 2024 1246 583 STAT_exp2 cells in log phase cells in stationnary phase 0.02 46.70 0.15 0.89 6080 213 479 890 1651 865 238 STATMMS cells in stationnary phase cells in stationnary phase 0.1%MMS 1h exposure 0.01 67.00 0.38 1.36 6075 428 722 1088 2634 1875 956 5 mock treatment Wild type 0.05% MMS 1h exposure 0.04 45.80 0.18 0.86 6079 158 446 859 1836 890 268 10 mock treatment Wild type 0.1% MMS 1h exposure 0.03 54.50 0.32 1.17 6079 355 653 972 2504 1669 750 20 mock treatment Wild type 0.2% MMS 1h exposure 0.02 97.50 0.32 1.31 6079 427 718 1078 2605 1845 950 10min mock treatment Wild type 0.1% MMS 10min exposure 0.07 67.00 -0.01 0.72 5860 116 409 970 951 391 101 30min mock treatment Wild type 0.1% MMS 30min exposure 0.03 97.70 0.12 0.87 6079 187 469 908 1544 767 227 60min mock treatment Wild type 0.1% MMS 60min exposure 0.02 46.90 0.20 0.96 6079 214 515 934 1967 1066 355 MNNG mock treatment Wild type 6.7µg/ml MNNG 1h exposure 0.04 24.90 0.11 0.70 6080 66 287 731 1305 549 115 MNNG_2 mock treatment Wild type 27µg/ml MNNG 1h exposure 0.02 63.30 0.15 1.10 6080 331 708 1195 1925 1165 471 t-BuOOH mock treatment Wild type 5mM t-BuOOH 1h exposure 0.01 80.60 0.11 1.42 6080 594 886 1247 2055 1352 673 4NQO mock treatment Wild type 2µg/ml 4NQO 1h exposure 0.13 24.30 0.13 0.60 6080 49 149 490 1118 385 87 4NQO_2 mock treatment Wild type 8µg/ml 4NQO 1h exposure 0.02 30.70 0.10 0.83 6080 120 422 956 1453 742 248 MMC mock treatment Wild type 2µg/ml MMC 1h exposure 0.10 12.10 -0.07 0.69 6080 162 473 1019 800 326 81 BCNU mock treatment Wild type 200µM BCNU 1h exposure 0.03 85.50 0.27 1.19 6076 357 620 964 2295 1436 593 g-ray mock treatment 30 kilorad gamma-ray exposure 0.01 57.80 -0.11 0.71 6080 182 484 1138 736 278 72

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